Sleep becomes unpredictable, hot flashes show up without warning, moods swing faster than they used to, and digestion doesn’t behave the same once perimenopause begins. But you can gracefully embrace this next step in womanhood with the best perimenopause supplements!
There’s no escaping perimenopause, or menopause itself. There are ways you can smooth out the symptoms and changes that come along with this rite of passage, though. So what are the best supplements for perimenopause? You should consider:
- Postbiotics for the gut-hormone communication
- Magnesium glycinate for relaxation and sleep quality
- Black cohosh for hot flash comfort
- Chasteberry for mood and cycle irregularity
- L-theanine for calm and mental clarity
- Vitamin D3, B6, and B12 for energy, mood, and bone support
resW perimenopause support brings each of these together in thoughtfully formulated amounts to help you feel more grounded and supported through every stage of life. Our physician-formulated supplement supports women stay cool, calm, and collected in their 40s and beyond. Learn more about the science behind resW today and how it can fit into your daily routine!
“My family noticed the change before I did. I wasn’t snapping at them as much. That’s when I realized my mood was steadier.” - Karen
“My periods were irregular and I felt drained. resW didn’t solve everything, but my energy and sleep improved. That helped me cope.” - Diana
“I didn’t expect much but after two months I was surprised. The hot flashes that had been constant slowed down and I started sleeping better. My mood was lighter too. It gave me back some peace of mind.” - Linda
What Are Perimenopause Supplements?
Perimenopause is the period of time when hormones start rising and falling unpredictably. It can occur anywhere from a woman’s late 30s to early 50s. You’ll know it’s here when you start noticing changes in sleep, mood, temperature control, energy, and the menstrual cycle.
A lot of women find that these symptoms come in waves. Some weeks are manageable, others feel completely off. This occurs because estrogen and progesterone start fluctuating as you age. The systems that depend on these hormones have to work harder as a result, so things start to fall out of sync.
Perimenopause supplements are designed to support the parts of the body most affected during this transition. They often include vitamins, minerals, botanicals, and gut-supportive ingredients that help with sleep, mood steadiness, stress, and daily comfort.
Key Ingredients in the Best Perimenopause Supplements
There are so many brands claiming to have come up with the best perimenopause supplements. You don’t have time to go through the trial and error of trying them all and hoping one actually delivers on its promises. So, just stick with supplements that feature proven ingredients for perimenopause support, such as:
Probiotics/Postbiotics
Probiotics support digestion, immune balance, and the gut-brain pathway. All of these things matter for women in perimenopause. Certain strains have stronger potential for mood, stress response, and even vasomotor symptoms.
But, postbiotics go even further as they contain the active compounds produced by beneficial bacteria. They’re not prone to the same issues as probiotics, like having to survive digestion. So, you end up with more consistent results.
We have a more thorough guide covering the best probiotics for perimenopause, but the long and short of it is that the L. plantarum RSB11® used in resW is well-studied for this stage of life*.
Magnesium
Everyone could benefit from getting more magnesium since this mineral influences hundreds of bodily functions. But women navigating perimenopause in particular find it effective, and the best perimenopause supplements should include the right form of magnesium.
Magnesium glycinate is highly bioavailable and shown to influence muscle relaxation, nerve signaling, and sleep quality. It may support a calmer nervous system without disrupting digestion.
Black Cohosh
This herb is backed by a wealth of research for easing hot flashes and night sweats. There are several clinical trials examining its role in easing vasomotor symptoms.
It’s not a hormone, and it won’t raise estrogen levels. What it can do, though, is interact with the pathways involved in blood vessel tone and neurotransmitter activity. The best supplements for perimenopause include this ingredient because it can support temperature regulation*.
Chasteberry
Chasteberry helps manage cycle-related symptoms by interacting with the pituitary gland, which affects how the body responds to shifting hormone levels. This ingredient can minimize mood swings, breast tenderness, and general PMS-like symptoms.
L-Theanine
This calming amino acid is one of the most popular ingredients in perimenopause supplements because it helps women stay calm even when life gets chaotic. It doesn’t have sedative-like properties, but it can subtly relax you by increasing alpha-wave activity in the brain.
B Vitamins
Vitamins B6 and B12 support energy production, nerve function, and cognitive clarity. There’s also reason to believe they’re effective vitamins for bloating, and more generally speaking, some of the best vitamins for gut health.
B6 supports neurotransmitters involved in mood, while B12 helps maintain red blood cell formation and steady energy levels. Deficiencies in either vitamin can make fatigue, brain fog (AKA meno brain), and stress sensitivity worse.
Vitamin D3
Vitamin D3 helps strengthen bones, bolster immune function, and regulate mood. A lot of women in perimenopause have low vitamin D levels without even knowing it, and this can make fatigue and mood swings more noticeable.
What Are the Best Supplements For Perimenopause Symptoms?
So, what are the best supplements for perimenopause? You don’t have to go out and round up individual vitamins, minerals, probiotics, and magnesium supplements. The best perimenopause supplements bring them all together in a single formula to streamline your regimen.
Better yet, you’re getting these ingredients in clinically proven forms and doses for results you can see and feel fast. Explore the best supplements for perimenopause symptoms as part of your routine.
resW
resW is built for women who want support across several common perimenopause symptoms rather than chasing them one at a time. Perimenopause symptoms tend to overlap, so a multi-pathway approach often works better than isolated ingredients.
Clinically studied postbiotic L. plantarum RSB11® is at the core of the formula. It supports healthy gut–hormone communication and plays a role in stress balance and daily comfort.* Unlike standard probiotics, it doesn’t have to survive digestion to be effective, either. It works more consistently.
The formula also includes magnesium glycinate for smoother nights, L-theanine for calmer thinking, black cohosh for hot flash comfort, and chasteberry for mood and cycle-related shifts.* We rounded out resW with vitamins D3, B6, and B12.
It’s physician-formulated and backed by several independent clinician evaluations. Some women who make it part of their daily ritual find themselves sleeping better, dealing with fewer mood swings, and staying cool during the day and night.*
resM
resM is our recommendation if you’re looking for the best perimenopause supplements for general relief. But maybe you’re struggling with cravings and metabolism at this stage of life. It’s more common than you might think.
So, what are the best supplements for perimenopause related to weight? Try our GLP-1 probiotic, resM. It was made for women dealing with appetite swings, persistent cravings, or the “food noise” that can increase during hormonal transitions.*
We’ve included our clinically studied heat-inactivated postbiotic at 16B CFU to support the pathways tied to appetite control and metabolic balance.* Chromium helps with the regulation of healthy blood sugar already in normal range, while white mulberry and fenugreek support carb handling and satiety.* Vitamins D3 and B12 round out the formula to fight fatigue and help you stay balanced.*
resM fits easily into a daily routine and helps women in perimenopause feel more in control of their appetite and energy levels.* Pair it with movement, a protein-rich diet, and consistent sleep habits for the best results!
resG
resG is built for women dealing with bloating, sluggish digestion, or discomfort.* These issues become more pronounced during perimenopause or while using GLP-1 therapies.
The formula starts with resistant potato starch, a prebiotic shown to support gut regularity and increase levels of beneficial bacteria linked to GLP-1 production.* Early data shows meaningful microbiome shifts, including increases in Akkermansia and Bifidobacterium. Both of these are linked to digestive comfort.*
Beetroot brings a natural energy lift by supporting nitric oxide production, so you can conquer the day without having to resort to caffeine. This effect is complemented by methylated B12 for even steadier energy.
resG works well as a morning or pre-workout drink to support digestion and support a smoother, more comfortable routine. It’s also one of the best supplements for perimenopause symptoms associated with weight and digestion.*
Bundles for Multi-Faceted Support
Not sure which of these is the best perimenopause supplement? Each has its place, which is why we’ve created bundles to help you try them all with one easy purchase.
resbiotic lets you use HSA/FSA funds for your order, too, so you can get the perimenopausal support you need without the financial stress. You can save even more and stay consistent in your regimen by subscribing to regular deliveries.
Don’t let perimenopause feel unsupported. Explore the best supplements for perimenopause symptoms today.
Wrapping Up Our Guide to the Best Supplements For Perimenopause Symptoms
In closing, what are the best supplements for perimenopause symptoms? It depends on which specific symptoms you’re struggling with the most. In general, though, the best perimenopause supplements address multiple challenges at once:
- Sleep disturbances
- Mood swings
- Brain fog and physical fatigue
- Hot flashes and night sweats
- Sluggish digestion and metabolism
resW is made with this mindset. Clinically validated ingredients, including a combination of vitamins, minerals, botanicals, and gut-supportive ingredients all work together to support this transition. Age gracefully with resbiotic!