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A brief history of microbiome science

The 1800s

In the 1840’s, Surgeon John Goodsir kicked off a debate on the presence and role of microorganisms in the gut with his observations of Sarcina Ventriculi in a patient’s stomach fluid.

The Early 1900s

Scientists observed associations between human longevity and yoghurt consumption (containing lactobacilli strains of bacteria).

The Mid 1900s

In the 1950’s, research accelerated. From faecal microbiota transplantation to the transfer of bacterial cultures to germ-free mice, research was primarily focused on the gut.

The 2000s

The NIH launched the Human Microbiome Project and 16S rRNA sequencing allowing scientists to easily and reliably characterize complex bacterial communities.

Microbiome & The Lungs

From the moment we take our first breath, the world around us is influencing our microbiome. The microbiome is a community of commensal, symbiotic, and pathogenic organisms that share our body space. In fact, there are more bacterial cells than human cells in a healthy human body.

Research in the field initially focused on the gut microbiome and digestive health but quickly expanded to studying other organs such as the skin brain and even lungs. In recent decades scientists discovered that complex communities of microbiota inhabit the lungs and help maintain homeostasis in immune response, microbial biosis, and lung health.*

Our Scientists

Dr. C Vivek Lal MD FAAP

CEO, Founder & CSO

Associate Professor & Director Pulmonary Microbiome Lab, University of Alabama at Birmingham

Dr. Amit Gaggar MD PhD

Chief Medical Officer

Endowed Professor, Pulmonary & Critical Care Medicine & Director, Program in Matrix Biology, University of Alabama at Birmingham

Dr. Teodora Nicola MD PhD MBA

Lead Scientist

Formerly NIH Funded Scientist at University of Alabama Birmingham

Dr. Mike Wells MD

Scientific Advisor
(Clinical Trials, Adult Lung Disease)

Associate Professor, Pulmonary & Critical Care Medicine, University of Alabama at Birmingham

Dr. Yvonne Huang MD

Scientific Advisor
(Microbiome, Adult Lung Disease)

Associate Professor, Pulmonary & Critical Care Medicine & Director Huang Microbiome Lab, University of Michigan

Dr. Namasivayam Ambalavanan MD

Scientific Advisor
(Pediatric Lung Disease)

Endowed Professor & Virginia Walker Chair in Pediatrics, University of Alabama at Birmingham

Dr. Casey Morrow PhD

Scientific Advisor
(Microbiome)

Professor Emeritus, Microbiome Resource Center & Cell Development & Integrative Biology, University of Alabama at Birmingham

Dr. Kent Willis MD

Scientific Advisor
(Gut-Lung Axis, Mycobiome)

Assistant Professor & Director, Willis Lung Lab, University of Alabama at Birmingham

Dr. Nirmal Sharma MD

Scientific Advisor
(Lung Transplant)

Assistant Professor Medical Director Lung Transplantation Program, Brigham & Women’s, Harvard University

Our Process

1 - Strain Development

Our strain bank is maintained with ResBiotic’s own proprietary deposits, all backed by clinical (in vivo) and laboratory (in vitro) proof of concept and safety data. Our blend is formulated by optimizing indicative biomarker responses in tissue cells to better optimize support for the lungs. All of our strains have had their full genomes sequenced.

2 - Botanical Formulation

Each capsule contains ancient botanical extracts produced in a cGMP (Current Good Manufacturing Processes) environment by FDA-certified suppliers, specifically processed for extended stability and probiotic longevity. The combination of probiotics and botanical extracts combine to create a truly unique formulation, tailored toward lung support.

3- Production

ResBiotic’s strain blend is produced via biofermentation at massive scale through optimizing fermentation temperature, pH, mother culture purity, and other factors. Each strain is enumerated and precision-blended to yield a consistent colony forming unit (CFU) count in each capsule, every time.

4 - Blend

Our science-derived dosage has been created based on nearly a decade of research into representative and mechanistic gut and lung models, both in vitro and in vivo. Because we value product integrity, we recommend you refrigerate our products to maintain maximum bacteria cell count and effectiveness. Important foods require extra care.

5 - Quality

Every batch of bacteria is cultured, concentrated, lyophilized (freeze-dried), jet-milled, analyzed for impurities, and precision-blended according to current Good Manufacturing Practices (cGMP) from FDA-compliant manufacturing facilities, and sent to you from our FDA-registered fulfillment center. We only release to the public products that have met stringent quality, purity, and analytical testing requirements.

6 - Safety

Our strains are recognized by the FDA as GRAS (Generally Recognized as Safe). Our products (and every ingredient in our products) has been clinically tested in humans and shown to be safe. Your safety and your lung health are our priority - in that order.

Questions?

What is the microbiome?

How can the gut microbiome affect lung health?

What kinds of diseases or conditions could be influenced by the gut-lung axis?