Prebiotic

How to Increase Akkermansia in the Gut

Learn how to increase Akkermansia in the gut, as this beneficial bacteria plays a role in everything from appetite regulation to gut barrier maintenance and repair. Your best bet is to feed Akkermansia muciniphila through a targeted supplement, like resbiotic’s resM. Learn what this physician-formulated and clinically studied GLP-1 probiotic can do for you today.

Why Do You Need to Increase Akkermansia in the Gut?

Akkermansia muciniphila feeds on a protein called mucin, which coats your intestinal wall.¹ It eats, tells your body to make more, and strengthens the gut barrier from the inside out.²

That barrier is in charge of what passes into your bloodstream and what stays out. Troublesome compounds can leak through a weakened gut barrier, taking a toll on metabolic health far beyond the digestive tract.²

Higher Akkermansia levels are linked to better glucose regulation, improved insulin sensitivity, and more consistent appetite signaling through short-chain fatty acid production.³ ⁴

Akkermansia also influences GLP-1 production - the hormone behind appetite and blood sugar control.⁵ Low populations of Akkermansia can cause gut permeability to rise, and metabolic markers tend to follow suit.²

Can You Boost Akkermansia Through Diet?

You can support it, but diet alone won't move the needle the way targeted supplementation can. Nevertheless, these food groups create better conditions for Akkermansia growth:

  • Prebiotic-rich: Oats, asparagus, garlic, onions - their inulin and beta-glucan content feeds Akkermansia directly
  • Polyphenol-rich: Berries, grapes, apples, green tea - polyphenols stimulate Akkermansia's metabolic activity⁶
  • Healthy fats: Almonds, chia seeds, flaxseeds, olive oil

Our full guide on foods to promote Akkermansia muciniphila covers each category in detail. Many of these also rank among the best fruits for gut health. But there’s a better option if you’re curious about how to increase Akkermansia in the gut…

How to Increase Akkermansia muciniphila With a Probiotic Supplement

Prebiotic potency can vary in food based on source, season, and preparation. Just too many variables. What survives cooking and digestion to reach the colon (where Akkermansia actually live) - is usually a fraction of what you ate. A supplement removes that variability.

resM features a postbiotic blend that boosted GLP-1 hormone production 300% in clinical studies.* It also includes vitamins D3 and B12, chromium, fenugreek, and white mulberry for well-rounded metabolic support.* 

Here are a few habits that support Akkermansia alongside supplementation:

  • 7-9 hours of sleep to maintain the mucus lining
  • Regular exercise to promote microbial diversity
  • Stress management - chronic stress disrupts gut bacterial balance
  • Staying hydrated to keep the mucus layer intact

Start with resM today. One capsule a day. See what a difference it can make for weight management and digestive health.

Parting Thoughts on How to Increase Akkermansia in the Gut

That covers how to increase Akkermansia in the gut from every angle - diet, supplementation, and daily habits. Remember, the bacteria is already in your gut. Your job is giving it what it needs to thrive, and that’s where resM comes into play. *

Related Resources

Does Akkermansia help you lose weight? | Tirzepatide vs Ozempic | Vitamins for gut health

References

  1. Derrien M, Vaughan EE, Plugge CM, de Vos WM. "Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium." Int J Syst Evol Microbiol. 2004;54(Pt 5):1469-1476. PubMed
  2. Everard A, Belzer C, Geurts L, et al. "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity." Proc Natl Acad Sci U S A. 2013;110(22):9066-9071. PMC
  3. Dao MC, Everard A, Aron-Wisnewsky J, et al. "Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology." Gut. 2016;65(3):426-436. PubMed
  4. Depommier C, Everard A, Druart C, et al. "Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study." Nat Med. 2019;25(7):1096-1103. PMC
  5. Plovier H, Everard A, Druart C, et al. "A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium improves metabolism in obese and diabetic mice." Nat Med. 2017;23(1):107-113. Nature Medicine
  6. Anhê FF, Roy D, Pilon G, et al. "A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice." Gut. 2015;64(6):872-883. PubMed

About the Authors

Kara Siedman, RDN, CDCES

Kara is the VP of Science and Partnerships at resbiotic. A Registered Dietitian Nutritionist and Certified Diabetes Care and Education Specialist, she brings a decade of clinical experience to every piece of content she writes. Her specialty is translational nutrition — turning peer-reviewed microbiome research into practical guidance people can actually use. Before joining resbiotic, she worked directly with patients managing respiratory, metabolic, and hormonal conditions, giving her firsthand understanding of the challenges these products are built to address.

C. Vivek Lal, MD, FAAP

Dr. Lal is the Founder and CEO of resbiotic and a double board-certified physician-scientist in Pediatrics and Neonatal-Perinatal Medicine. He is a tenured Professor of Pediatrics and Executive in Residence at the University of Alabama at Birmingham, where he directs the Microbiome & Discovery Labs — one of the nation's leading research centers for translating microbiome science into clinical therapeutics. His NIH-funded research has produced 20+ patents and reshaped how medicine understands the gut-lung axis. He is also the Founder and CEO of Alveolus Bio, a biotech company developing inhaled biotherapeutics for pulmonary conditions.